IKAROS SETS THE THRESHOLD FOR NEGATIVE B-CELL SELECTION BY REGULATION OF THE SIGNALING STRENGTH OF THE AKT PATHWAY

Ikaros sets the threshold for negative B-cell selection by regulation of the signaling strength of the AKT pathway

Abstract Inhibitory phosphatases, such as the inositol-5-phosphatase SHIP1 could potentially contribute to B-cell acute lymphoblastic leukemia (B-ALL) by raising the threshold for activation of the autoimmunity checkpoint, allowing malignant cells with strong oncogenic B-cell receptor signaling to escape negative selection.Here, we show that SHIP1

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Performance comparison of measurement microphones and microbarometers for sound pressure measurements near wind power plants

Reliable assessment of airborne infrasound emitted by natural and technical sources has been gaining importance, while technology is limited and regulations are not sufficient in the infrasound frequency Accessories range.This paper provides a comparison of measurement microphones and microbarometers used for infrasound measurements in the field ne

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Malignant Peripheral Nerve Sheath Tumor: MRI and CT Findings

This is a case report of a 56-year-old male with hypertension who presented Educational Toys with urinary retention and bowel incontinence.CT and MRI of the abdomen and pelvis showed a large complex cystic and solid enhancing mass in the right presacral space.Pathology biopsy result showed malignant peripheral nerve sheath tumor (MPNST) with extens

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